U0126: A Novel Selective and Potent Inhibitor of MAP Kinase Kinase MEK

Mitogen-activated protein kinases (MAPKs) are involved in a number of cell signaling pathways. These enzymes are activated by dual phosphorylation of threonine and tyrosine residues in response to a multitude of extracellular stimuli. Activation of MAPKs are mediated by another set of enzymes referred to as MAPK kinases or MEKs. In this article, we introduce MEK Inhibitor U0126, a compound that exhibits potent MEK inhibitor activity both in vitro and in vivo.

Promega Notes 69, 6.