Promega has recently introduced the Anti-ACTIVE® Caspase-3 pAb, which is intended for use as an in situ marker for the detection of apoptosis. The antibody detects the active form of caspase-3 that occurs in apoptotic cells and thus provides a simple method for detection of apoptosis in situ. Here we describe this new Anti-ACTIVE® antibody and discuss the advantages of this method in the context of other technologies available for verifying apoptosis.
Promega Notes 75, 17–19.
Terry Riss, Rich Moravec, and Martha O'Brien